Spontaneous Lymphoma in a SMP30 Knock-Out C57BL/6 Mouse

Abstract 70-weeks-old female C57BL6 senescence marker protein 30 knock out mice exhibited anorexia, lethargy and enlarged abdomen because of an intraperitoneal mass. On necropsy, the mouse revealed a large brown-whitish mass located on mesentery. The also systemic metastasis spread over in various organs. microscopic findings, neoplastic masses were mainly composed round cells characterized by severe anisokaryosis, narrow cytoplasm, nuclei, prominent nucleoli, numerous mitotic figures (13-15 400X field). Consequently, present case was diagnosed as metastatic lymphoma arising from mesenteric lymph node, tumor to other organs such intestine, kidney thoracic cavity. According previous studies, SMP30 plays important role inhibiting cancer both human mouse. Taken together, it seems that can be used valuable asset for evaluating potential risks depletion developing lymphoma.